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Pharmacological Research


Horse Chestnut Seed Extract

Results of Clinical Study

Fig. 8. Persistence of acute signs and symptoms in a double-blind, placebo-controlled, parallel group trial in patients with acute hemorrhoidal attacks after treatment with either 40 mg aesein tid orally (n=38) or matching placebo n=34) placebo | aescin
Reference: Pharmacological Research, Vol. 44, No. 3, 2001

"A double-blind, placebo-controlled study of 80 people with symptomatic hemorrhoids evaluated the use of a horse chestnut product providing 40 mg of aescin 3 times daily. The results indicated that use of horse chestnut produced noticeable subjective improvements in pain, bleeding, and swelling within a week; within 2 weeks, the benefits were visible by objective examination."
Reference: NYU Langone Medical Center
Link: http://surgery.med.nyu.edu/content?ChunkIID=21758

"Horse chestnut, a tree native to the Balkan Peninsula, has been used in traditional medicine for centuries. The seed extract is a popular dietary supplement used to support vascular functions. Horse chestnut should not be confused with sweet chestnut. Escin, also known as Aescin, a natural mixture of triterpenoid saponins isolated from the seed of the horse chestnut and the major active principle, was shown to have anti-inflammatory (1), neuroprotective, antitumor effects, and enhances the efficacy of gemcitabine. Data from clinical trials suggest efficacy of horse chestnut seed extract against chronic venous insufficiency. Conclusions from systematic reviews and meta analysis state that horse chestnut extract is a safe and well tolerated treatment for CVI."
Reference: Memorial Sloan-Kettering Cancer Center
Link: www.mskcc.org/cancer-care/herb/horse-chestnut

"The active ingredients in horse chestnut appear to be a group of chemicals called saponins, of which aescin is considered the most important. Aescin appears to reduce swelling and inflammation. It's not exactly clear how aescin might work, but theories include "sealing" leaking capillaries, improving the elastic strength of veins, preventing the release of enzymes (known as glycosaminoglycan hydrolases) that break down collagen and open holes in capillary walls, decreasing inflammation, and blocking other various physiological events that lead to vein damage. Horse chestnut is most often used as a treatment for venous insufficiency . This is a condition associated with varicose veins, when the blood pools in the veins of the leg and causes aching, swelling, and a sense of heaviness. While horse chestnut appears to reduce these symptoms, no studies have evaluated whether it can make visible varicose veins disappear, or prevent new ones from developing. Because hemorrhoids are actually a form of varicose veins, horse chestnut is used for them as well, and one double-blind, placebo-controlled study suggests that it may be effective."
Reference: Tufts Medical Center

Link: http://www.tuftsmedicalcenter.org/apps/Healthgate/Article.aspx?chunkiid=21758

"Horse chestnut seed extracts (HCSE) are used clinically to relieve the subjective symptoms and reduce the objective signs of chronic venous insufficiency. The active component of the extract is thought to be the triterpenic saponin, aescin. HCSE has been shown to exhibit venotonic, vascular protective, anti-inflammatory, and free-radical scavenging properties...These properties make HCSE ideal for the treatment of both varicose veins and hemorrhoids."
Reference: Alternative Medicine Review .Volume 6, Number 2 .2001
Link: http://www.thorne.com/altmedrev/.fulltext/6/2/126.pdf

"Patients also showed decreased symptoms such as fatigue, tenderness, and pruritus. One study showed the relative equivalency of using HCSE compared with grade II compression stockings for treatment of CVI...In Europe, Horse Chestnut Seed Extract (HCSE) has also been used in the form of a topical gel, lotion, or ointment to reduce inflammation and discomfort associated with varicose veins, phlebitis, and hemorrhoids."
Reference: Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. 2011
Link: http://www.ncbi.nlm.nih.gov/books/NBK92761/

Witch Hazel Leaf Extract

"Witch hazel (H. virginiana) contains considerable amounts of tannin (see the details of preparation in Section 18.3.1), making it a useful astringent. It has been used topically to soothe inflammation of the skin and mucous membranes in disorders such as varicose veins and hemorrhoids."
Reference: Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. 2011
Link: http://www.ncbi.nlm.nih.gov/books/NBK92761/

Witch hazel (Hamamelis virginiana), applied topically or used as a sitz bath, may temporarily shrink hemorrhoids and relive symptoms. Many "pads" used to treat hemorrhoids contain witch hazel."
Reference: University of Maryland Medical Center
Link: http://www.umm.edu/altmed/articles/hemorrhoids-000077.htm#ixzz2B2SEsBtx

"Witch hazel extract, high in tannins and volatile oils, is a well-known medicinal tree from the deciduous forest of Atlantic North America. Witch hazel has a long therapeutic tradition and is used primarily for its astringent, anti-inflammatory, and local hemostatic effects."
Reference: Alternative Medicine Review .Volume 6, Number 2 .2001
Link: https://studyres.com/doc/14154009/hemorrhoids-and-varicose-veins

Bilberry Fruit Extract

"In a 4-week, double-blind, placebo-controlled trial of 40 people with hemorrhoids, use of an extract made from the bioflavonoid-rich herb bilberry significantly reduced hemorrhoid symptoms as compared to placebo."
Reference: Villalba G. Medicina (Mex) 1974;54:73-76
Link: http://www.umm.edu/altmed/articles/hemorrhoids-000077.htm#ixzz2B2SEsBtx

"The anthocyanins in bilberry contribute to most of its pharmacological activities. Anthocyanin has anti-inflammatory, vasoprotective, and antioxidant effects. It has demonstrated free radical scavenging and inhibition of cAMP phosphodiesterase actions."
Reference: Memorial Sloan-Kettering Cancer Center
Link: http://www.mskcc.org/cancer-care/herb/bilberry-fruit

"Although bilberry constituents have multiple pharmacological actions, most of the research has focused on the anthocyanosides. Extracts containing anthocyanosides have been shown to possess strong antioxidant properties, stabilize collagen fibers and promote collagen biosynthesis, decrease capillary permeability and fragility, and inhibit platelet aggregation. Anthocyanosides and other bilberry leaf constituents prevent the release and synthesis of pro-inflammatory compounds such as histamine, prostaglandins, and leukotrienes. In addition, bilberry leaf decoctions administered orally have been shown to lower blood glucose levels."
Reference: Alternative Medicine Review .Volume 6, Number 5 .2001

Link: http://www.thorne.com/altmedrev/.fulltext/6/5/500.pdf

"Inflammation is a protective mechanism, but chronic inflammation increases oxidative stress and underlies many age-related diseases, including CVD and cancer (Libby, Ridker, and Maseri 2002; Halliwell and Gutteridge 2007; Aggarwal et al. 2009). Many studies suggest that anthocyanins, the predominant phenolic compounds found in bilberry, have anti-inflammatory effects (Karlsen et al. 2007; Chen et al. 2008; Dreiseitel et al. 2008; Kim et al. 2009)."

Reference: Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition.

Links: https://www.ncbi.nlm.nih.gov/books/NBK92770/

Vitamin C

“Vitamin C (ascorbate, ascorbic acid) is a major water-soluble antioxidant that also increases extracellular collagen production and is important for proper immune cell functioning (Hoffman, 1985; Cameron, et al., 1979).”

Link: https://riordanclinic.org/research-study/vitamin-c-research-ivc-protocol/

“The healing of musculoskeletal tissues, such as bone, tendons, and ligaments, is dependent on the capacity of collagen synthesis and cross-linking.7,20,34 Poorly developed extracellular matrices derived from collagen can lead to inadequate tissue structures and biomechanical strength, which can result in unsatisfactory outcomes and an increased risk for reinjuries. Basic science investigations on the biochemical pathways after a musculoskeletal injury have suggested that vitamin C, also known as ascorbic acid, may enhance collagen synthesis and soft tissue healing.22,24,28,31

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204628/

“Vitamin C is an essential part of skin health both as a small molecular weight antioxidant and as a critical factor for collagen synthesis. Vitamin C contributes to photoprotection, decreases photodamage, and is needed for adequate wound healing.”
Link: https://lpi.oregonstate.edu/mic/health-disease/skin-health/vitamin-C


Hesperidin exhibits several pharmacological actions such as antihyperlipidemic, cardioprotective, antihypertensive, antidiabetic activities, which are mainly attributed to an antioxidant defense mechanism and suppression of pro-inflammatory cytokine production. Various randomized crossover trials have shown the beneficial effects of hesperidin, which mainly results from anti-inflammatory and anti-atherogenic actions.

Links: https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/hesperidin

Hesperidinis also rich in the fruit skin, which is used as a component of Chinese herbal medicine and has been used for medication for a long time.54 In Europe and Australia, hesperidin is used to treat vascular diseases, in the USA hesperidin is distributed as a dietary supplement with vitamin C.
Links: https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/hesperidin

Butcher's Broom

Butcher’s broom has a long history of clinical use as a treatment for hemorrhoids, and its use for treating this condition has been approved by the German Commission E.4 In one open-label multicenter study of 124 patients, 69 percent of the patients rated butcher’s broom as having good or excellent efficacy.5 Seventy-five (75) percent of the treating physicians rated this herb’s efficacy similarly. In addition, 92 percent of the physicians rated butcher’s broom as safe and well-tolerated. For this study, patients took 6 capsules per day of a product containing 150 mg of butcher’s broom for 3 days and then reduced their dose to 4 capsules per day. Statistically significant improvement in a variety of symptoms (such as pain, local signs, overall severity, etc.) was seen after 7 days of treatment. While a single study does not prove efficacy, the very favorable observations of treating physicians combined with a long history of clinical use are reasons to recommend that patients consider using butcher’s broom as an internal treatment for hemorrhoids.”

Link: http://www.sld.cu/galerias/pdf/sitios/mednat/botanical_treatments.pdf

Considering the study duration of three months it is concluded, that ruscus extract (Butcher’s Broom), in the recommended daily dosage according to the German monograph, is a safe and effective treatment for patients suffering from chronic venous insufficiency.”

Links: https://www.ncbi.nlm.nih.gov/pubmed/12040966

“Despite continuous improvement in our knowledge and management of chronic venous disease (CVD), certain areas, such as the role of muscarinic receptors in the pathology and treatment of CVD, remain unexplored. The symposium "The place of Ruscus extract, hesperidinmethyl chalcone, and vitamin C in the management of CVD", held at the Annual Meeting of the European Venous Forum on 7-9 July 2016 in London, presented an update on the pathophysiology of CVD and highlighted how the combination of Ruscus extract, hesperidin methyl chalcone, and vitamin C (Ruscus/HMC/VitC; Cyclo 3® Fort), may counteract the deleterious processes underlying CVD.”
Links: https://www.ncbi.nlm.nih.gov/pubmed/28124877


“The researchers from the Department of Pharmacological and Biomolecular Science at the University of Milan stimulated in vitro human gastric and epithelial cells with pro-inflammatory cytokines and treated them with ENOVITA® at increasing concentrations for 6 hours. The results demonstrated a strong capacity of the extract to reduce IL-8 release.”

Thanks to their multiple mechanism of action, dietary polyphenols are extensively recognized to have a potential role in the protection from chronic conditions and several studies already reported their possible role in modulating challenging processes at gastrointestinal level.” – commented Antonella Riva, Senior Scientific Researcher at Indena – “The promising results presented for the first time at this international conference suggest a possible clinical testing of our highly standardized grape seed extract from Vitis vinifera L. ENOVITA® in subjects with inflammatory-related disorders of gastrointestinal tract.

Links: http://www.indena.com/news/potential-health-benefits-of-enovita-for-gastrointestinal-tract/

“Scientific studies have shown that the antioxidant power of proanthocyanidins is 20 times greater than vitamin E and 50 times greater than vitamin C. Extensive research suggests that grape seed extract is beneficial in many areas of health because of its antioxidant effect to bond with collagen, promoting youthful skin, cell health, elasticity, and flexibility. Other studies have shown that proanthocyanidins help to protect the body from sun damage, to improve vision, to improve flexibility in joints, arteries, and body tissues such as the heart, and to improve blood circulation by strengthening capillaries, arteries, and veins. The most abundant phenolic compounds isolated from grape seed are catechins, epicatechin, procyanidin, and some dimers and trimers.”

Links: https://www.ncbi.nlm.nih.gov/pubmed/14977436

“GSPE significantly inhibited the propagation of thrombus induced by IVC ligation in a rat model. The antithrombotic properties of proanthocyanidins are likely to be directly associated with endothelial protection and regeneration, platelet aggregation, and inhibition of inflammatory cell and thrombus adhesion. Thus, proanthocyanidins may have a clinical application in DVT treatment.”

Links: https://www.ncbi.nlm.nih.gov/pubmed/21095090

GSPs are endowed with high antioxidant activity, orders of magnitude higher than vitamin C, and have been extensively investigated for their capacity to interfere with the development of the cardiovascular disease (CVD) phenotype associated with the oxidation of membrane lipids (endothelial dysfunction, formation of oxidized LDL, and activation of phagocytic cells)”

Links: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792515/

HemRid - Hemorrhoid Relief Supplement

$24.95 USD

  • Description
  • Ingredients

    HemRid helps from the inside out increasing circulation and relieving itching, burning, and discomfort. It gets into the bloodstream to strike the hemorrhoid at its source. HemRid is perfect to use with Tucks Medicated Pads, Preparation H, Doctor Butlers Ointment and Mayinglong Musk.


    HemRid's blend of natural, clinically tested ingredients attack hemorrhoids at their core to provide rapid long term relief. HemRid effectively works with hemorrhoid pillows, hemorrhoid creams, or hemorrhoid cushion treatments. HemRid is also safe to use with hemorrhoid wipes, hemorrhoid suppositories, and hemorrhoid ointment. HemRid can be used for both internal and external hemorrhoids.


    Developed using clinically tested ingredients, recommended by world-renowned Physician Dr. Mitchel Schwindt, and trusted by over 30,000 customers, HemRid can help you take back control of your life and avoid the burning and discomfort that derails your day.


    If you're tired of the burning and itching of hemorrhoids, you'll love the soothing power of HemRid's all-natural ingredients. HemRid is manufactured in an FDA registered facility in the United States and is GMP certified. We are proud to bring you a powerful hemorrhoid fighting supplement made in the USA.


    We're so confident that HemRid will relieve your painful symptoms, we're talking all of the risk. Try HemRid against other hemorrhoid relief supplements like Hemtab, Hem relief, Venapro, Avatrol and more for 120 days. If you're not satisfied, just let us know and we'll give you a refund. No questions asked.

  • Horse Chestnut Seeds (20% Extract), Witch Hazel Powder (leaf, stem and twig), Bilberry Fruit (4:1 extract)


Used for centuries, modern lab tests show how this natural compound reduces pain, inflammation, and bleeding fast from the inside-out—it gets the blood flowing.



Native to forests in North America, it fights inflammation from within the membranes of your skin to shrink your hemorrhoids naturally from the inside-out.



Proven to protect blood vessels and reduce inflammation by stopping the buildup of harmful, excess antibodies, Bilberry has strong antioxidant properties.



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